Base frequency and dose on clinical response. Intravascular hemolysis in immune thrombocytopenic purpura ITP. Warning does not apply to Rh o D -negative patients in suppression of Rh isoimmunization.
Pregnancy Cat. Suppression of Rh isoimmunization in nonsensitized Rh o D -negative women in appropriate obstetrical conditions, unless the fetus or father is known to be Rh o D -negative. Suppression of Rh isoimmunization in Rh o D -negative females after accidental transfusion of Rh o D -positive blood products. Pregnancy: IU at 28 weeks gestation; if given early in pregnancy, repeat every 12 weeks. Post-delivery: IU as soon as possible preferably within 72 hrs, up to 28 days of an Rh incompatible delivery.
Amniocentesis or other manipulation late in pregnancy after 34 weeks gestation , abortion: IU as soon as possible within 72 hrs. Chorionic villus sampling, amniocentesis before 34 weeks gestation , threatened abortion: IU as soon as possible, repeat every 12 weeks during pregnancy.
Transfusion: IV route: IU micrograms every 8 hours; or IM route: IU micrograms every 12 hours; for both: total dose based on exposure see full labeling ; give within 72 hours. Rh o D -positive patients. IgA deficiency. Perform a dipstick urinalysis to monitor for hematuria and hemoglobinuria at baseline and 2 hours, 4 hours, and prior to the end of the monitoring period.
Alert patients and monitor the signs and symptoms of IVH including back pain, shaking chills, fever, and discolored urine or hematuria. Maltose in IGIV products has been shown to give falsely high blood glucose levels in certain types of blood glucose testing systems.
It may carry a risk of transmitting infectious agents, e. In Rh o D -positive patients with ITP, side effects related to the destruction of Rh o D -positive red blood cells, most notably decreased hemoglobin, can be expected.
In most cases, the red blood cell destruction is believed to occur in the spleen.
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